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Dr Abu-Bakr Abu-Median

Job: Lecturer in Biomedical Science (VC2020)

School/department: School of Allied Health Sciences

Address: De Montfort University, The Gateway, Leicester, LE1 9BH

T: +44 (0)116 2078009

E: abu-bakr.abu-median@dmu.ac.uk

W: www.dmu.ac.uk/hls

 

Personal profile

Dr Abu-Median joined De Montfort University as a VC2020 Lecturer in Biomedical Science in 2017. He is a veterinarian and a molecular microbiologist with several years of research experience coupled with teaching undergraduate veterinary, medical and pharmacy students and supervision of PhD students.

 

Abu-Bakr obtained his BVSc from the University of Khartoum, Sudan, where he started his academic career and co-established a private veterinary practice as a farm animal vet. He followed his MSc in Applied Molecular Microbiology from The University of Nottingham with a PhD in Molecular Bacteriology from the University of Bristol, while based at the Compton Laboratory of the Institute for Animal Health (now The Pirbright Institute). Dr Abu-Median remained at the Institute as a Research Scientist until 2010, then joined the School of Veterinary Medicine and Science, University of Nottingham as a Research Fellow to continue his research under funding from the EU and the BBSRC until 2016.

 

Major research expertise in Microbial Molecular Diagnostics and Structure-Function Analysis of Microbial Virulence Factors coupled with Computational Homology Modelling. Current research focuses on developing DNA-based assays and microarrays for portable high–throughput molecular diagnostic and multi-pathogen screening devices (Lab-on-a-Chip) for use in clinical settings, patient bedside and in the field. As an Associate Fellow of the Higher Education Academy, Dr Abu-Median developed a particular interest in methods of supervising postgraduate students.

Research group affiliations

  • Biomedical and Environmental Health Group
  • Biomolecular Technology Group
  • Infectious Diseases Research Group

Publications and outputs 

  1. Timothy A. Giles, Alex D. Greenwood, Kyriakos Tsangaras, Tom C. Giles, Paul A. Barrow, Duncan Hannant, Abu-Bakr Abu-Median, Lisa Yon (2016) Detection of a Yersinia pestis gene homologue in rodent samples. Peer J. 4:e2216; DOI 10.7717/peerj.2216.
  1. Ouchene N, Ouchene-Khelifi NA, Khelifi M, Zeroual F, Bitam I, Benakhla A, Kaidi R, Abu-Median A (2016) Prevalence and Molecular Characterization of Cryptosporidium in Dairy Cattle from Farms in Algeria. Journal of the Faculty of Veterinary Medicine, Kafkas University 22, 703-707.  (DOI: 10.9775/kvfd.2016.15192). 
  1. Giles T., Yon L., de Bree F., Bossers A., Hannant D., Barrow P., Abu-Median A. (2015) Development of a DNA-based microarray for the detection of zoonotic pathogens in rodent species. Molecular and Cellular Probes 29, 427-437. pii: S0890-8508(15)30023-2. doi: 10.1016/j.mcp.2015.07.005.

  2. R. Kelanemer, N. Antoine-Moussiaux, N. Moula, A.A.K. Abu-Median, Ch. Hanzen and R. Kaidi (2015) Effect of Nutrition on Reproductive Performance During the Peri-Partum Period of Female Camel (Camelus dromedarius) in Algeria. Journal of Animal and Veterinary Advances 14, 192-196. 
  1. Rouabah A., Kaidi R., Abu-Median A., Djezzar M. (2015) Inductor at direct ovarian action, The chorionic gonadotropin in artificial reproduction of African Cat Fish (Clarias Gariepinus, BURCHELL 1822). International Journal of Zoology and Research 5, 11-18. 
  1. Osama. H. A. Ali, Huwaida E.E. Malik, Abu-Bakr A. K. Abu-Median and Barri M. N. Hamid. (2012) Mortality rates following deutectomy in anaesthetized and non- anaesthetized day old chicks. U of K. J. Vet. Med. & Anim. Prod. 3, 82-91. 
  1. Barrow PA., Abu-Median A. (2011) New viral pathogens from wildlife.Bull Mem Acad R Med Belg. 166(10-12), 399-403. 
  1. Armesto M., Evans S., Cavanagh D., Abu-Median A., Keep S. and Britton P. (2011) A recombinant avian infectious bronchitis virus expressing a heterologous spike gene belonging to the 4/91 serotype. PLoS One 6(8):e24352 (doi:10.1371/journal.pone.0024352).

  2. Ward, P. N., Abu-Median, A. and Leigh, J. A. (2008) Structural consideration of the formation of the activation complex between the staphylokinase-like streptococcal plasminogen activator PadA and bovine plasminogen. Journal of Molecular Biology 381, 734-747. 
  1. Watson, M., Dukes, J. P., Abu-Median, A., King, D. P. and Britton, P. (2007) DetectiV: visualisation, normalisation and significance testing for pathogen-detection microarray data, Genome Biology 8:R190 (doi:10.1186/gb-2007-8-9-r190). 
  1. van Dieman P. M., Dziva, F., Abu-Median, A., Wallis, T. S., van den Bosch, H., Dougan, G., Chanter, N., Frankel, G. and Stevens, M. P. (2007) Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic Escherichia coli O157:H7 or O26:H-. Veterinary Immunology and Immunopathology 116, 47-58. 
  1. Abu-Bakr Abu-Median, Pauline M. van Diemen, Francis Dziva, Isabella Vlisidou, Timothy S. Wallis and Mark P. Stevens. (2006) Functional analysis of lymphostatin homologues in enterohaemorrhagic Escherichia coli. FEMS Microbiology Letters 258, 43-49. 
  1. Philip N. Ward, Terence R. Field, Everett L. Rosey, Abu-Bakr Abu-Median,Ruth A. Lincoln and James A. Leigh. (2004) Complex interactions between bovine plasminogen and Streptococcal plasminogen activator PauA. Journal of Molecular Biology 342, 1101-1114.

 

Key research outputs

  1. Giles T., Yon L., de Bree F., Bossers A., Hannant D., Barrow P., Abu-Median A. (2015) Development of a DNA-based microarray for the detection of zoonotic pathogens in rodent species. Molecular and Cellular Probes 29, 427-437. pii: S0890-8508(15)30023-2. doi: 10.1016/j.mcp.2015.07.005. 
  1. Armesto M., Evans S., Cavanagh D., Abu-Median A., Keep S. and Britton P. (2011) A recombinant avian infectious bronchitis virus expressing a heterologous spike gene belonging to the 4/91 serotype. PLoS One 6(8):e24352 (doi:10.1371/journal.pone.0024352). 
  1. Ward, P. N., Abu-Median, A. and Leigh, J. A. (2008) Structural consideration of the formation of the activation complex between the staphylokinase-like streptococcal plasminogen activator PadA and bovine plasminogen. Journal of Molecular Biology 381, 734-747. 
  1. Watson, M., Dukes, J. P., Abu-Median, A., King, D. P. and Britton, P. (2007) DetectiV: visualisation, normalisation and significance testing for pathogen-detection microarray data, Genome Biology 8:R190 (doi:10.1186/gb-2007-8-9-r190). 
  1. Abu-Bakr Abu-Median, Pauline M. van Diemen, Francis Dziva, Isabella Vlisidou, Timothy S. Wallis and Mark P. Stevens. (2006) Functional analysis of lymphostatin homologues in enterohaemorrhagic Escherichia coli. FEMS Microbiology Letters 258, 43-49.

Research interests/expertise

  • Antimicrobial resistance – molecular biology and epidemiology
  • Commercialisation of science
  • Infectious diseases
  • Microbial biotechnology and Synthetic biology
  • Microbial genomics
  • Molecular diagnostics
  • Pathogen biology
  • Pathogen discovery
  • Zoonosis, reverse zoonosis and One Health 

Areas of teaching

  • Applied biotechnology (Advanced Biomedical Science MSc/PG Dip/PG Cert)
  • Evidence-based practice (Advanced Biomedical Science MSc/PG Dip/PG Cert)
  • Microbiology
  • Molecular biology
  • Molecular genetics and genomics

Qualifications

  • BVSc (University of Khartoum)
  • MSc (University of Nottingham)
  • PhD (University of Bristol)
  • AFHEA

Membership of professional associations and societies

  • Microbiology Society
  • Association of Veterinary Teaching and Research Work
  • Sudan Veterinary Association

Professional licences and certificates

Associate Fellow, Higher Education Academy

Conference attendance

  1. Abu-Bakr Abu-Median and Paul Barrow. A platform for high-throughput surveillance of infectious epizootic and zoonotic diseases. Oral presentation at The 2nd International Conference on Epidemiology and Infectious Diseases, 18th-20th September 2015, Shanghai, China.

 

  1. Abu-Bakr Abu-Median, Kyriaki Nomikou, Peter Mertens and Paul Barrow. One Platform, Multiple Zoonotic Pathogens, Several Host Species.Oral presentation at the 2nd Global Risk Forum One Health Summit, 17th-20th November 2013, Davos, Switzerland.

 

  1. Giles, Timothy; Abu-Median, Abu-Bakr; Yon, Lisa; and Barrow, Paul. Development of a DNA based Microarray for the Detection of Zoonotic Pathogens in Rodent Species. Oral presentation at the 2nd Global Risk Forum One Health Summit, 17th-20th November 2013, Davos, Switzerland.

 

  1. Ayral Florence, Giles Tim, Bicout J Dominique, Zilber Anne-Laure, Widen Frederik, Pounder Kieran, Aubert Dominique, Djelouadji Zoheira, Kodjo Angeli, Berny Philippe, McElhinney Lorraine, Abu-Median Abu-Bakr, Yon Lisa and Artois Marc. Disease risk mapping for surveillance of zoonotic pathogens in Norway rats; preliminary results in France (2010 – 2012).Oral presentation at the 2nd Global Risk Forum One Health Summit, 17th-20th November 2013, Davos, Switzerland.

 

  1. Debra Bourne, Abu-Bakr Abu-Median, Dolores Gavier-Widén, Henrik Uhlhorn and Lisa Yon. The Importance of Developing a Standardised Sample Collection Protocol for Wildlife Disease Surveillance. Oral presentation at the 2nd Global Risk Forum One Health Summit, 17th-20th November 2013, Davos, Switzerland.

 

  1. A. Abu-Median and T. Giles, Effective sample handling, processing and manipulation for detecting multiple pathogens in animal tissues. A webinar for Qiagen, 7th November 2013, World-wide broadcast.

 

  1. Abu-Bakr Abu-Median, Nucleic Acid-based Pathogen Detection Microarrays at the University of Nottingham. Oral presentation at theWildTech Technology Transfer Workshop at the Joint WDA EWDA Conference 22nd – 27th July 2012, Lyon, France.

 

  1. Peter P. C. Mertens, Narender Maan, Kyriaki Nomikou, Karin Darpel, Eva Veronesi , Veronique Moulin, Abu-Bakr Abu-Median, Houssam Attoui and Sushila Maan. Type-specific diagnostic assays for bluetongue virus, by real-time RT-PCR and microarray: Virulent challenge strains for evaluation of BTV-8 vaccines. Orbivac Meeting, London School of Hygiene and Tropical Medicine, 22nd June 2011.

 

  1. Abu-Median A., Watson M., Cavanagh D. and Britton P. A newly-developed diagnostic microarray as a single platform for rapid detection and characterisation of avian and other veterinary viruses. In the proceedings of the XVIth World Veterinary Poultry Association Congress8th – 12th November 2009, Marrakech, Morocco.

 

  1. Abu-Bakr Abu-Median, Michael Watson and Paul Britton. Development, Application and Evaluation of an in-house Virus Microarray for Detection and Characterisation of Veterinary Viruses. Poster presented at the Health Protection Agency’s 12th Conference, 25th June 2009, London, UK.

 

  1. Abu-Bakr Abu-Median and Paul Britton. The Avian Coronavirus IBV as a Model for an In-House Virus Detection Microarray.Oral presentation at the 6th International Symposium on Avian Corona- and Pneumoviruses and Complicating Pathogens, 15th June 2009, Rauischholzhausen, Germany.

 

  1. Abu-Median, A. A. & Britton, P. (2009). The avian coronavirus infectious bronchitis virus as a model for an in-house virus detection microarray. VI International Symposium on Avian Corona- and Pneumoviruses and complicating pathogens, pp.125-129. Rauischholzhausen, Germany.

 

  1. Paul Britton and Abu-Bakr Abu-Median. Coronavirus Detection. Oral presentation at the Defra BioSecurity Chip Meeting, 28th April 2009, London. 

 

  1. Abu-Bakr Abu-Median. Development, Application and Evaluation of an in-house Virus Microarray. Oral presentation at the Epizone Training Workshop, Veterinary Laboratories Agency, 4th December 2008.

 

  1. Abu-Bakr Abu-Median. Development, Application and Evaluation of an in-house Virus Microarray: using avian and other viruses. Oral presentation at the VLA – IAH Surveillance Day, Veterinary Laboratories Agency, 24th November 2008.

 

  1. Abu-Bakr Abu-Median, Michael Watson, Dave Cavanagh, Paul Britton. Virus detection by microarray: nidoviruses as a model. In the Proceedings of the XIth International Nidovirus Symposium, 22-27 June 2008, Oxford.

 

  1. A. Abu-Median and P. Britton. Pan-viral Microarray: a tool for virus detection and discovery of new viruses. In the proceedings of the 62nd Annual Conference of the Association of Veterinary Teaching and Research Work (AVTRW), 17-20th March 2008 Scarborough, UK.

 

  1. Abu-Bakr Abu-Median, Dave Cavanagh and Paul Britton. The Role of Microarrays in Diagnosis and Surveillance for Poultry Pathogens. Oral presentation at the Poultry Disease Group Meeting, London, 28th November 2007.

 

  1. Paul Britton and Abu-Bakr Abu-Median. Development of a microarray for the detection of exotic, endemic, zoonotic and emerging viruses in avian and other species. Oral presentation at the CEVA-Phylexia Meeting, 23rd November 2007, Budapest, Hungary.  

 

  1. D. Cavanagh, F. Culver, A. Abu-Median and P. Britton. Current and future ways of detecting enteric and other viruses of poultry.  The XVth Congress of the World Veterinary Poultry Association, held from the 12-15th September 2007, Beijing, China.

 

  1. A. Abu-Median, J. P. Dukes, M. Watson, R. Card, M. Banks, D. P. King and P. Britton. Virus Detection and Characterisation by Microarray Analysis. In the proceedings of the 3rd European Congress of Virology, held from the 1st – 5th September 2007, Nuremberg, Germany.

 

  1. M. Watson, J. P. Dukes, A. Abu-Median, P. Britton and D. P. King. DetectiV: Visualisation, normalisation and analysis of pathogen detection microarray data. The 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & 6th European Conference on Computational Biology (ECCB)", held from the 21st-25th July 2007, in Vienna, Austria.

 

  1. Paul Britton and Abu-Bakr Abu-Median. Development of a microarray for the detection of exotic, endemic, zoonotic and emerging viruses in avian and other species. Oral presentation at the Defra Meeting, 3rd July 2007, London.

 

  1. J. P. Dukes, A. Abu-Median, M. Watson, R. Card, P. Britton, M. Banks, and D. P. King. Development of microarrays for viral characterisation. The 1st Annual meeting of EPIZONE, held from the 30th May to 1st June 2007, Pulawy, Poland.

 

  1. Abu-Bakr Abu-Median. Development of a microarray for the detection of exotic, endemic, zoonotic and emerging viruses in avian and other species. Oral presentation at the Joint VLA-IAH Molecular Epidemiology Science Event,Veterinary Laboratories Agency, 26th February 2007.

 

  1. J. P. Dukes, R. Card, A. Abu-Median, P. Golby, J. Nuñez-García, M. Watson, P. Britton, M. Banks, D. Cavanagh and D. P. King. Development of a microarray for viral characterisation. A poster presented at the 7th International Congress of Veterinary Virology of the European Society for Veterinary Virology, 24th-27th September 2006, Lisbon, Portugal.

 

  1. Mark P. Stevens, Andrew J. Roe, Pauline M. van Diemen, Abu-Bakr Abu-Median, David L. Gally & Timothy S. Wallis (2003) Role of Efa1 homologues in the colonisation of calves by Escherichia coli O157:H7. In the abstracts of the Society for General Microbiology 152nd meeting, Edinburgh.

 

  1. A. A. Abu-Median, P. N. Ward, E. Reich and J. A. Leigh (2002) PadA: a staphylokinase-like streptococcal plasminogen activator with ruminant specificity. In the abstracts of the 6th American Society for Microbiology Conference on Streptococcal Genetics, Asheville, USA.

 

  1. Ward P. N., Abu-Median A. A., Leigh J. A. (2002) Genetic Analysis of Streptococcus uberis plasminogen activators. In the abstracts of the 6th American Society for Microbiology Conference on Streptococcal Genetics, Asheville, USA.

Professional esteem indicators

  • Associate Editor, Open Veterinary Journal
  • Reviewer, BMC Microbiology
Abu-Bakr 800

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